h1.Rd
Compute grid points for first interim analysis in a group sequential design
h1(r = 18, theta = 0, I = 1, a = -Inf, b = Inf)
r | Integer, at least 2; default of 18 recommended by Jennison and Turnbull |
---|---|
theta | Drift parameter for first analysis |
I | Information at first analysis |
a | lower limit of integration (scalar) |
b | upper limit of integration (scalar |
A tibble
with grid points in z
, numerical integration weights in w
,
and a normal density with mean mu = theta * sqrt{I}
and variance 1 times the weight in w
.
Mean for standard normal distribution under consideration is mu = theta * sqrt(I)
# Replicate variance of 1, mean of 35 h1(theta = 5, I = 49) %>% summarise(mu = sum(z * h), var = sum((z - mu)^2 * h))#> # A tibble: 1 x 2 #> mu var #> <dbl> <dbl> #> 1 35.0 1.00# Replicate p-value of .0001 by numerical integration of tail h1(a = qnorm(.9999)) %>% summarise(p = sum(h))#> # A tibble: 1 x 1 #> p #> <dbl> #> 1 0.000100