Compute grid points for first interim analysis in a group sequential design

h1(r = 18, theta = 0, I = 1, a = -Inf, b = Inf)

Arguments

r

Integer, at least 2; default of 18 recommended by Jennison and Turnbull

theta

Drift parameter for first analysis

I

Information at first analysis

a

lower limit of integration (scalar)

b

upper limit of integration (scalar > a)

Value

A tibble with grid points in z, numerical integration weights in w, and a normal density with mean mu = theta * sqrt{I} and variance 1 times the weight in w.

Details

Mean for standard normal distribution under consideration is mu = theta * sqrt(I)

Examples

# Replicate variance of 1, mean of 35 h1(theta = 5, I = 49) %>% summarise(mu = sum(z * h), var = sum((z - mu)^2 * h))
#> # A tibble: 1 x 2 #> mu var #> <dbl> <dbl> #> 1 35.0 1.00
# Replicate p-value of .0001 by numerical integration of tail h1(a = qnorm(.9999)) %>% summarise(p = sum(h))
#> # A tibble: 1 x 1 #> p #> <dbl> #> 1 0.000100