All functions

ahr_blinded()

Blinded estimation of average hazard ratio

gridpts()

Grid points for group sequential design numerical integration

gs_b()

gs_b: Default boundary generation

gs_design_ahr()

Group sequential design using average hazard ratio under non-proportional hazards

gs_design_npe()

Group sequential design computation with non-constant effect and information

gs_design_nph()

Fixed and group sequential design under non-proportional hazards

gs_info_ahr()

Information and effect size based on AHR approximation

gs_power_ahr()

Group sequential design power using average hazard ratio under non-proportional hazards

gs_power_npe()

Group sequential bound computation with non-constant effect

gs_power_nph()

Group sequential design power under non-proportional hazards

gs_prob()

Group sequential boundary crossing probabilities

gs_spending_bound()

Derive spending bound for group sequential boundary

gsdmvn

gsdmvn: A package for group sequential design under non-proportional hazards (NPH)

h1()

Initialize numerical integration for group sequential design

hupdate()

Update numerical integration for group sequential design