Articles
Designing for time-to-event endpoints
These vignettes provide an introduction to designing group sequential trials with time-to-event endpoints using gsDesign.
- Overview of survival endpoint design
- Integer sample size and event counts
- Basic time-to-event group sequential design using gsSurv
- Power Computation for Group Sequential Survival Designs
- Futility and harm bounds for overall survival monitoring
- Selective bound testing at interim analyses
- A cure model calendar-based design
Other
Other vignettes.
- A gentle introduction to group sequential design
- gsDesign package overview
- Spending function overview
- Conditional power and conditional error
- Conditional error spending functions
- Two-sample normal sample size
- Multiplicity graphs
- Graphical testing for group sequential design
- Vaccine efficacy trial design
- Binomial two arm trial design and analysis
- Binomial SPRT