Articles
General information
Introductory and broad overview materials.
Designing for time-to-event endpoints
These vignettes provide an introduction to designing group sequential trials with time-to-event endpoints using gsDesign.
- Overview of survival endpoint design
- Integer sample size and event counts
- Basic time-to-event group sequential design using gsSurv
- Power Computation for Group Sequential Survival Designs
- Futility and harm bounds for overall survival monitoring
- Selective bound testing at interim analyses
- A cure model calendar-based design
- Reproducing PROC SEQDESIGN survival designs in gsDesign
Exact binomial designs with spending
Exact binomial workflows, including spending-function-based designs.
Multiple hypothesis testing
Graphical and related multiple testing workflows.
Conditional power and adaptation
Interim decision support and adaptation-oriented examples.