Articles
General information
Introductory and broad overview materials.
Designing for time-to-event endpoints
These vignettes provide an introduction to designing group sequential trials with time-to-event endpoints using gsDesign.
- Overview of survival endpoint design
- Basic time-to-event group sequential design using gsSurv
- Planning enrollment and follow-up for survival designs
- Selective bound testing at interim analyses
- Integer sample size and event counts
- Power Computation for Group Sequential Survival Designs
- Futility and harm bounds for overall survival monitoring
- A cure model calendar-based design
- Reproducing SAS PROC SEQDESIGN survival designs in gsDesign
Exact binomial designs with spending
Exact binomial workflows, including designs based on spending functions.
Multiple hypothesis testing
Graphical and related multiple testing workflows.
Conditional power and adaptation
Interim decision support and adaptation-oriented examples.