Package index

Sample size calculation

Functions for calculating fixed sample sizes for negative binomial outcomes.

sample_size_nbinom()

Sample size calculation for negative binomial distribution

print(<sample_size_nbinom_result>)

Print Method for sample_size_nbinom_result Objects

summary(<sample_size_nbinom_result>)

Summary for sample_size_nbinom_result Objects

print(<sample_size_nbinom_summary>)

Print Method for sample_size_nbinom_summary Objects

Group sequential design

Functions for extending fixed designs to group sequential designs.

gsNBCalendar()

Group sequential design for negative binomial outcomes

toInteger()

Convert Group Sequential Design to Integer Sample Sizes

summary(<gsNB>)

Summary for gsNB Objects

print(<gsNBsummary>)

Print Method for gsNBsummary Objects

Simulation

Tools for simulating trial data.

nb_sim()

Simulate recurrent events with fixed follow-up

nb_sim_seasonal()

Simulate recurrent events with seasonal rates

Analysis

Functions for analyzing trial data, including blinded sample size re-estimation and interim analysis.

blinded_ssr()

Blinded sample size re-estimation for recurrent events

calculate_blinded_info()

Calculate blinded statistical information

mutze_test()

Wald test for treatment effect using negative binomial model (Mütze et al.)

cut_data_by_date()

Cut simulated trial data at a calendar date

cut_completers()

Cut data for completers analysis

cut_date_for_completers()

Find calendar date for target completer count

compute_info_at_time()

Compute Statistical Information at Analysis Time

get_analysis_date()

Find calendar date for target event count

gsDesign re-exports

Spending functions and utilities re-exported from the gsDesign package for convenience.

reexports gsDesign sfBetaDist sfCauchy sfExponential sfExtremeValue sfExtremeValue2 sfGapped sfHSD sfLDOF sfLDPocock sfLinear sfLogistic sfNormal sfPoints sfPower sfStep sfTDist sfTrimmed sfTruncated sfXG1 sfXG2 sfXG3 gsBoundSummary

Objects exported from other packages