gsDesign Technical Manual

This is the gsDesign package manual. The initial intent is to start with the material in the gsDesign manual written with an early version of the package written in LaTeX and to update appropriately.

Author

Keaven M. Anderson

Welcome

Welcome to the online version of the gsDesign Technical Manual by Keaven M. Anderson. You can download the PDF version here.

The gsDesign package supports group sequential clinical trial design. While there is a strong focus on designs using \(\alpha\)- and \(\beta\)-spending functions, Wang-Tsiatis designs, including O’Brien-Fleming and Pocock designs, are also available. The ability to design with non-binding futility rules is an important feature to control Type I error in a manner acceptable to regulatory authorities.

The book was written by Keaven M. Anderson. The translation from the original LaTeX version to bookdown was largely done by Fang Xiao, with help from Yilong Zhang and Nan Xiao. Later, Nan Xiao migrated the content from bookdown to Quarto.